Fmoc-PEG-Propionic Acid

Fmoc-PEG-Propionic Acid series, exemplified by N-Fmoc-PEG8-CH₂CH₂COOH, is a heterobifunctional reagent specifically designed for solid-phase peptide synthesis (SPPS). This compound features an Fmoc-protected amine group for controlled chain elongation and a terminal carboxylic acid function for versatile conjugation, connected through an extended PEG-based spacer. Its key advantages include minimized steric hindrance due to the elongated architecture, tunable PEG length (n), and enhanced solubility of peptide-resin intermediates.