Maleimide-NH-PEG-OH

Mal-NH-PEGn-OH is a heterobifunctional PEG derivative featuring a maleimide group and a hydroxyl terminus, enabling sequential conjugation strategies such as thiol-specific binding via Michael addition followed by hydroxyl-directed modifications. Its key advantages include orthogonal reactivity for flexible biomolecular assembly, tunable spacer length (n), and enhanced solubility, though the maleimide group requires protection from hydrolysis and may undergo retro-Michael reactions in certain conditions.