Thiol-PEG-OH

HS-PEGn-OH is a heterobifunctional PEG derivative featuring a thiol group and a hydroxyl terminus, enabling sequential conjugation strategies such as maleimide-thiol coupling followed by hydroxyl-directed modifications for applications like surface functionalization and protein PEGylation. Its key advantages include orthogonal reactivity for flexible biomolecular assembly, tunable spacer length (n), and enhanced solubility, though the thiol group requires protection against oxidation and may necessitate reducing conditions for stability.