Fmoc-PEG-TFP

Fmoc-PEG-TFP is a heterobifunctional reagent designed for solid-phase peptide synthesis (SPPS), combining Fmoc amine protection with highly reactive TFP ester-mediated conjugation for efficient amide bond formation. Its key advantages include enhanced hydrolysis resistance compared to NHS esters, tunable spacer length (n), and high coupling efficiency with sterically hindered amines, though the TFP ester requires synthesis under anhydrous conditions and the Fmoc group necessitates piperidine deprotection.