Methyltetrazine-PEG-Amine

Methyltetrazine-PEG-Amine combines a methyltetrazine group for rapid inverse electron-demand Diels-Alder reactions with a primary amine for conjugation to carboxyl groups or other reactive sites. The PEG spacer in Methyltetrazine-PEG-Amine provides enhanced solubility, reduced steric hindrance, and tunable chain length. Methyltetrazine-PEG-Amine is particularly suitable for constructing bioorthogonal probes, pretargeted imaging agents, and functional biomaterials requiring fast click kinetics under physiological conditions.