Fmoc-PEG-OH

Fmoc-PEG-OH is a protected heterobifunctional PEG derivative designed for solid-phase peptide synthesis (SPPS), enabling temporary amine protection during chain elongation while allowing carboxyl-terminal modifications. Its key advantages include Fmoc-group deprotection under mild basic conditions, tunable spacer length (n), and enhanced solubility for peptide fragments, though the Fmoc group requires alkaline treatment for removal and may exhibit sensitivity to prolonged exposure to piperidine.