Bis-Maleimide PEG

Mal-PEGn-CH₂CH₂Mal is a homobifunctional crosslinker designed for conjugating thiol-containing molecules (e.g., proteins, peptides, or thiolated nanoparticles) via dual maleimide-thiol coupling. Its key advantages include high reactivity for efficient bispecific bridging, tunable spacer length (n) to optimize distance between entities, and enhanced stability of thioether bonds, though the maleimide groups are sensitive to hydrolysis and may require anhydrous handling to prevent degradation.