DBCO-PEG-Acid

DBCO-PEG-Acid is a heterobifunctional PEG reagent, also known as Cyclooctyne-functional PEG-acid, featuring a DBCO group for copper-free click chemistry with azides and a carboxylic acid for covalent attachment to amines. The carboxylic acid can be activated for amide bond formation, enabling versatile bioconjugation strategies. DBCO-PEG-Acid reagents are widely used in peptide modification, surface functionalization, and biomaterial development, especially for sensitive biological systems where copper catalysts must be avoided.