DSG-PEGs

DSG-PEGs are a specialized subclass of cationic polyplex-forming reagents widely employed in gene delivery systems (e.g., for plasmid DNA or siRNA) in both in vitro and in vivo settings, where their PEG segments enhance colloidal stability and biocompatibility. Representative structures such as DSG-PEG45-OMe integrate methoxy-capped PEG chains of defined length to improve serum compatibility and reduce cytotoxicity compared to traditional polyethylenimine (PEI) vectors, although transfection efficiency remains dependent on PEGylation density and molecular architecture.