Methyltetrazine-PEG-Maleimide

Methyltetrazine-PEG-Maleimide combines a methyltetrazine group for fast inverse electron-demand Diels-Alder cycloaddition with a maleimide terminus for thiol-specific conjugation. The PEG spacer in Methyltetrazine-PEG-Maleimide provides enhanced solubility and reduces steric constraints between functional groups. Methyltetrazine-PEG-Maleimide is widely used for constructing dual-functional probes, pre targeted imaging agents, and biomolecular assemblies that require orthogonal thiol and tetrazine reactivity.

Tetrazine PEG Maleimide reagents are widely used for site-specific conjugation with thiol-containing molecules, such as cysteine residues on proteins or peptides. This allows precise control over bioconjugation, making them valuable in applications like antibody-drug conjugates (ADCs) and protein modifications. These reagents are also key in developing new materials, such as hydrogels and advanced polymers for biomedical uses.