Thiol-PEG-Acid

The HS-PEGn-CH₂CH₂COOH series, exemplified by HS-PEG8-CH₂CH₂COOH, is a heterobifunctional PEG derivative engineered for dual conjugation strategies. This reagent enables sequential thiol-specific reactions (e.g., with maleimides or gold nanoparticles) followed by carboxyl-mediated amide bond formation with amines, making it ideal for constructing complex biomolecular assemblies. Key advantages include orthogonal reactivity for versatile bioconjugation, tunable PEG spacer length (n), and reduced steric hindrance afforded by the extended ethylene chain.