Thiol-PEG-Amine HCl salt

HS-PEGn-CH₂CH₂NH₂·HCl is a heterobifunctional PEG salt designed for dual conjugation, enabling sequential thiol-mediated coupling (e.g., with maleimides) and amine-based amidation via the protonated amino group. Its key advantages include enhanced water solubility due to the hydrochloride salt form, tunable spacer length (n), and orthogonal reactivity for biomolecular assembly, though the thiol group requires reducing conditions to prevent oxidation and the amine may need deprotonation for efficient nucleophilic reactions.