mPEG-Propionic Acid

mPEGₙ-OCH₂CH₂COOH is a key subclass of carboxyl-functionalized polyethylene glycol reagents, with representative structures such as mPEG₁₁-OCH₂CH₂COOH featuring an extended ethylene glycol spacer that enhances binding accessibility and reduces steric hindrance. These linkers are widely utilized for conjugating amine-containing biomolecules (e.g., proteins, peptides) via carbodiimide-mediated coupling, effectively improving hydrophilicity and pharmacokinetic profiles while maintaining pH-dependent conjugation efficiency.