Site Specific Linker

Site-specific linkers enable precise, selective conjugation of payloads (e.g., drugs, dyes) to biomolecules (e.g., antibodies, proteins) at defined sites, ensuring uniform payload attachment, preserved biological activity, and batch-to-batch consistency. They are critical for advanced drug development (e.g., antibody-drug conjugates, ADCs) and bioconjugation, with common types including bis-sulfone and dibromo-maleimide linkers (targeting cysteine residues, e.g., Bis-sulfone-PEGn-NHS Ester, Dibromo-Mal-PEGn-Azide) and NHS ester-functionalized variants (reacting with amines). Some linkers include PEG spacers to enhance solubility or azide groups for click chemistry compatibility.

PurePEG offers site-specific linkers with diverse functional groups, supporting tailored conjugation strategies for research and therapeutic applications.