Non-PEG Linkers

Non-PEG Linkers are a diverse category of molecular connectors independent of polyethylene glycol (PEG) backbones, featuring structures such as Maleimide-(CH₂)ₙ-COOH and other non-PEG spacers that provide distinct properties including rigidity, tailored biodegradability, or specific cleavage profiles.  These linkers are particularly valuable in applications where PEG is undesirable—due to potential immunogenicity, stability concerns, or regulatory constraints—enabling customized bioconjugation strategies in drug development, diagnostic assays, and biomaterial engineering.  Their structural diversity significantly expands the toolbox for designing targeted therapeutics, responsive probes, and advanced functional materials.