Amino-PEG-Propionic Acid

The H₂N-PEGn-CH₂CH₂COOH series, exemplified by H₂N-PEG24-CH₂CH₂COOH, is a heterobifunctional PEG derivative engineered for dual conjugation applications. Its extended spacer architecture effectively minimizes steric interference, making it particularly suitable for constructing targeted complexes such as ligand-drug conjugates or modified peptides. Key advantages include orthogonal reactivity for sequential bioconjugation, customizable PEG length (n), and enhanced solubility for hydrophobic molecules. It is important to note that the amine group may require protection during carboxyl-activated conjugation steps to prevent unintended cross-linking.