Tetrazine Linker

Tetrazine Linkers are a specialized class of bioorthogonal reagents featuring tetrazine groups that enable rapid, catalyst-free inverse electron demand Diels-Alder (IEDDA) reactions with trans-cyclooctene (TCO) dienophiles. Representative structures like Methyltetrazine-Phenylacetic Acid combine high reactivity with modular design, making them particularly valuable for live-cell labeling, pretargeted imaging, and in vivo bioconjugation applications.