Methyltetrazine-PEG-Propargyl

Methyltetrazine-PEG-Propargyl integrates a methyltetrazine group for fast inverse electron-demand Diels-Alder reactions with a propargyl terminus for copper-catalyzed azide-alkyne cycloaddition. The PEG spacer in Methyltetrazine-PEG-Propargyl offers improved hydrophilicity and tunable chain length for optimal molecular spacing. Methyltetrazine-PEG-Propargyl enables sequential orthogonal click chemistry strategies in multistep bioconjugation, probe assembly, and biomaterials engineering.