Biotin-LC-NHS ester

Biotin-LC-NHS Ester is a heterobifunctional reagent designed for efficient bioconjugation with amine-containing molecules (e.g., antibodies, proteins), combining the reduced steric hindrance of a long-chain (LC) spacer with rapid NHS ester-mediated amine coupling. Its key advantages include enhanced streptavidin binding accessibility, tunable spacer length for optimal orientation, and high reactivity under mild conditions, though the NHS ester group requires anhydrous handling due to hydrolysis sensitivity.