THP-SS

A dual-responsive linker incorporating acid-labile tetrahydropyran (THP) protection and a redox-sensitive disulfide bond (also known as a Tetrahydropyranyl-SS reagent or THP-SS). Enables pH-controlled deprotection in acidic environments (e.g., tumor tissues, endosomes) followed by glutathione-mediated payload release. Optimized for constructing multi-stage drug delivery systems that respond to both acidic pH and intracellular reducing conditions.

Similar Products: TFP-SS, TCO-SS, Tfa-SS, Tos-SS