Biotin-LC-LC-NHS ester

Biotin-LC-LC-NHS Ester is a specialized heterobifunctional reagent designed for bioconjugation with amine-containing biomolecules (e.g., antibodies, peptides), featuring an extended double long-chain (LC-LC) spacer to minimize steric hindrance and maximize streptavidin binding efficiency. Its key advantages include exceptional flexibility for challenging targets (e.g., membrane proteins, densely modified nanoparticles), high NHS ester reactivity under mild conditions, and enhanced detection sensitivity in assays like pull-downs and diagnostics, though the elongated hydrophobic spacer may require optimization to mitigate potential non-specific binding.