# PubMed records per publication year, PubMed E-utilities esearch (queried 2026-11-13). PurePEG Research, purepeg.com/research/pegylation-publication-trends/. License: CC BY 4.0.
# PEGylation query: pegylation[tiab] OR pegylated[tiab] OR pegylating[tiab]
# Click chemistry query: "click chemistry"[tiab] OR "click chemistry"[mh]
# PROTACs query: PROTAC[tiab] OR PROTACs[tiab] OR "proteolysis targeting chimera"[tiab] OR "proteolysis targeting chimeras"[tiab] OR "proteolysis targeting chimera"[mh]
# Antibody-drug conjugates query: "antibody-drug conjugate"[tiab] OR "antibody-drug conjugates"[tiab] OR "antibody drug conjugate"[tiab] OR "antibody drug conjugates"[tiab]
# Lipid nanoparticles query: "lipid nanoparticle"[tiab] OR "lipid nanoparticles"[tiab]
year,all_pubmed_records,pegylation,click,protac,adc,lnp,pegylation_per_100k,click_per_100k,protac_per_100k,adc_per_100k,lnp_per_100k
2000,532637,84,0,2,4,14,15.8,0.0,0.4,0.8,2.6
2001,547644,146,1,3,2,16,26.7,0.2,0.5,0.4,2.9
2002,565486,211,3,3,0,27,37.3,0.5,0.5,0.0,4.8
2003,594602,291,4,3,4,32,48.9,0.7,0.5,0.7,5.4
2004,639789,471,15,4,6,39,73.6,2.3,0.6,0.9,6.1
2005,700541,520,26,6,4,56,74.2,3.7,0.9,0.6,8.0
2006,750409,649,68,1,17,57,86.5,9.1,0.1,2.3,7.6
2007,786776,771,102,2,12,74,98.0,13.0,0.3,1.5,9.4
2008,837237,827,169,5,19,88,98.8,20.2,0.6,2.3,10.5
2009,877684,860,224,3,20,123,98.0,25.5,0.3,2.3,14.0
2010,942305,1133,324,9,27,175,120.2,34.4,1.0,2.9,18.6
2011,1020837,1318,538,2,63,213,129.1,52.7,0.2,6.2,20.9
2012,1090477,1384,572,3,105,257,126.9,52.5,0.3,9.6,23.6
2013,1150052,1460,663,3,167,294,127.0,57.6,0.3,14.5,25.6
2014,1205839,1574,754,7,240,354,130.5,62.5,0.6,19.9,29.4
2015,1258053,1561,745,10,310,334,124.1,59.2,0.8,24.6,26.5
2016,1285489,1400,774,13,371,462,108.9,60.2,1.0,28.9,35.9
2017,1304355,1264,733,36,386,444,96.9,56.2,2.8,29.6,34.0
2018,1351720,1221,731,69,481,408,90.3,54.1,5.1,35.6,30.2
2019,1418985,1107,761,164,574,454,78.0,53.6,11.6,40.5,32.0
2020,1641273,1066,739,279,693,587,64.9,45.0,17.0,42.2,35.8
2021,1787563,1132,725,388,855,842,63.3,40.6,21.7,47.8,47.1
2022,1783688,999,625,486,891,1005,56.0,35.0,27.2,50.0,56.3
2023,1697890,922,713,616,1131,1156,54.3,42.0,36.3,66.6,68.1
2024,1740364,896,850,819,1413,1570,51.5,48.8,47.1,81.2,90.2
2025,1882514,1068,1008,1059,2020,2207,56.7,53.5,56.3,107.3,117.2