# Registered clinical studies by start year, ClinicalTrials.gov API v2 (data timestamp 2026-11-12T10:00:05). PurePEG Research, purepeg.com/research/pegylation-clinical-trials-trend/. License: CC BY 4.0.
# Queries (query.term): PEGylated = PEGylated ; LNP = "lipid nanoparticle" OR "lipid nanoparticles" OR LNP OR LNPs ; ADC = "antibody-drug conjugate" OR "antibody-drug conjugates" . 2026 = actual or anticipated start dates registered so far.
start_year,pegylated_studies,lnp_studies,adc_studies,pegylated_strict_intervention_match,lnp_strict,adc_strict
2005,67,0,1,42,0,1
2006,61,1,1,54,0,0
2007,75,0,0,49,0,0
2008,62,0,2,45,0,1
2009,68,0,6,53,0,5
2010,57,0,5,42,0,3
2011,107,1,8,83,0,6
2012,98,2,14,63,0,9
2013,87,2,28,53,1,20
2014,84,2,21,48,0,14
2015,71,2,26,50,0,14
2016,67,0,32,46,0,17
2017,48,1,21,25,1,12
2018,36,3,43,26,1,26
2019,39,4,28,28,2,20
2020,52,15,49,33,5,30
2021,51,21,59,28,14,33
2022,51,20,66,36,7,30
2023,36,18,91,24,5,41
2024,36,17,119,28,6,45
2025,36,27,150,25,11,59
2026,37,52,210,25,10,92

phase_group_2021_2025_starts,pegylated,lnp,adc
Phase 1 or 1/2,48,61,232
Phase 2,68,13,155
Phase 2/3 or 3,39,17,58
Phase 4,12,6,3
No phase (N/A or observational),43,6,37

start_year,studies_with_an_approved_pegylated_drug_name_as_intervention (query.intr; data timestamp 2026-11-13T10:00:06)
2005,182
2006,224
2007,220
2008,254
2009,223
2010,209
2011,248
2012,230
2013,195
2014,157
2015,198
2016,199
2017,168
2018,156
2019,164
2020,157
2021,176
2022,169
2023,176
2024,156
2025,156
2026,163
query.intr,"peginterferon OR pegfilgrastim OR pegaspargase OR ""certolizumab pegol"" OR pegloticase OR pegvisomant OR pegvaliase OR pegcetacoplan OR ""avacincaptad pegol"" OR ropeginterferon OR eflapegrastim OR ""calaspargase pegol"" OR lonapegsomatropin OR palopegteriparatide OR navepegritide OR pegunigalsidase OR elapegademase OR ""methoxy polyethylene glycol-epoetin beta"" OR naloxegol OR pegaptanib OR peginesatide OR ""liposomal doxorubicin"" OR ""pegylated liposomal doxorubicin"" OR zilucoplan OR pegzilarginase OR ""rurioctocog alfa pegol"" OR ""damoctocog alfa pegol"" OR ""turoctocog alfa pegol"" OR ""nonacog beta pegol"""

hand_check_sample_seed_20261112,nct_id,modality_is_an_intervention
pegylated,NCT00617591,yes
pegylated,NCT07434063,yes
pegylated,NCT00027742,yes
pegylated,NCT01458080,no
pegylated,NCT00561353,yes
pegylated,NCT04547829,yes
pegylated,NCT04965714,yes
pegylated,NCT00770536,yes
pegylated,NCT02488382,yes
pegylated,NCT00573378,yes
pegylated,NCT04077905,yes
pegylated,NCT00538603,yes
pegylated,NCT02023099,no
pegylated,NCT01497925,yes
pegylated,NCT02309450,no
pegylated,NCT01852604,no
pegylated,NCT05535764,yes
pegylated,NCT02714712,yes
pegylated,NCT00736333,yes
pegylated,NCT05226013,yes
lnp,NCT04148833,"no: LDE lipid nanoemulsion, not an LNP"
lnp,NCT07703514,yes
lnp,NCT07580261,yes
lnp,NCT03823040,no: solid lipid nanoparticles
lnp,NCT07332663,yes
lnp,NCT04934111,yes
lnp,NCT05057182,yes
lnp,NCT05171959,yes
lnp,NCT05526066,yes
lnp,NCT07053072,yes
lnp,NCT04486833,yes
lnp,NCT06747858,yes
lnp,NCT07077369,yes
lnp,NCT05142319,yes
lnp,NCT07665515,yes
lnp,NCT04601051,yes
lnp,NCT05231369,yes
lnp,NCT04821674,yes
lnp,NCT04566276,yes
lnp,NCT07887347,yes
adc,NCT04323956,no
adc,NCT05060276,yes
adc,NCT07844551,yes
adc,NCT06597721,yes
adc,NCT07890246,yes
adc,NCT05155839,yes
adc,NCT05489211,yes
adc,NCT06780085,yes
adc,NCT05773937,yes
adc,NCT07581574,yes
adc,NCT04479267,yes
adc,NCT06377566,yes
adc,NCT07610616,yes
adc,NCT04266249,"unclear, counted as no"
adc,NCT07823270,yes
adc,NCT04042701,yes
adc,NCT05564858,yes
adc,NCT07701122,yes
adc,NCT07913568,yes
adc,NCT05434234,yes